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Consequently, any agent that targets NOXs would be a promising therapeutic approach for cancer

These groups of natural compounds offer promising anticancer effects and have potential as standalone or adjuvant therapies

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An increase in eukaryotic translation initiation factor 3 subunit F (EIF3F) and Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 (MALT1) was also demonstrated to be reduced by BBR treatment of murine mast cells (100 M), suggesting that through inhibition of eotaxin and pro-inflammatory cytokines and the inflammatory cells recruited, BBR is able to improve AD symptoms, and this may be due to the downregulation of EIF3F and MALT1 [58]

Ethics declarations Competing interests The authors declare no competing interests

Soluble TNF mediates amyloid-independent, diet-induced alterations to immune and neuronal functions in an Alzheimer's disease mouse model