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GLP-1 receptor agonists are now widely prescribed for individuals with type 2 diabetes and weight loss, with a 700% increase in usage reported in the United States between 2019 and 2023. These medications alter glucose metabolism, gastric motility, and sympathetic tone, which may lead to unique uptake patterns on PET-CT

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Mechanistic studies indicate that RhoA exacerbates vascular permeability in OA by inhibiting endothelial cell adhesion proteins and actin filaments and by promoting endothelial ferroptosis (97)