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BPC-157 work centres on local angiogenic signalling, with Hsieh and colleagues (J Mol Med, 2017) reporting VEGFR2 upregulation and internalisation in human endothelial cells, and Chang and colleagues (J Appl Physiol, 2011) reporting increased focal adhesion kinase and paxillin phosphorylation in cultured rat tendon fibroblasts

We constructed two such adducts (Juglone-C2-Glutathione-adduct and Juglone-C3-Glutathione-adduct) in silico as shown in Scheme1 and docked them to ChaC1 at the glutathione binding site to generate the last two model systems

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