Attia is host of the health and medicine podcast, The Drive , and the author of the book, Outlive: The Science & Art of Longevity." This transcript is currently under human review and may contain errors
If you are choosing a low dose initially, you can administer it all at once
This can be used alongside GLP-1 medications to manage blood sugar levels and weight
3- Effects on Liver Steatosis and Overall Metabolic Health : Beyond weight and glucose control, retatrutide has shown promise in reducing liver fat accumulation [5] (liver steatosis), a frequent complication in obesity and diabetes
[PUBMED Abstract] Christensen KD, Roberts JS, Shalowitz DI, et al.: Disclosing individual CDKN2A research results to melanoma survivors: interest, impact, and demands on researchers
a decrease in sperm motility (due to mitochondria damage resulting in a reduction in ATP [energy], and damage to the tail a decrease in sperm viability (how long they remain alive) an increase in mid-piece morphology defects (comprised of mostly mitochondria) deleterious effects on sperm capacitation and acrosome reaction (aka sperms ability to fertilize the egg) increased sperm DNA damage and apoptosis (cell death) And could contribute to possible birth defects It should be noted that almost all human ejaculate contains reactive oxygen species (ROS), primarily produced from the above-mentioned lifestyle and environmental factors ( consumption of sugars and oxidized vegetable oils, smoking, alcohol, exposure to environmental toxins, high or chronic emotional stress, circadian rhythm dysregulation (poor sleep), lack of exercise, infections, and a lack of antioxidant intake ), as well as from abnormally shaped sperm present (meaning, if there is a high % of abnormally shaped sperm, or poor morphology, more reactive oxygen species (ROS) will be present, and these days, most sperm samples contain a large % of abnormally shaped sperm)
