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Lancet 366 , 12791289 (2005)

PMID: 20524875

Sleep Biol

In summary, these findings demonstrated that SFN has antidepressant- and anxiolytic-like [anxiety reducing] activities in stressed mice model of depression, which likely occurs by inhibiting the hypothalamic-pituitary-adrenal (HPA) axis and inflammatory response to stress.[16] It was determined via an ELISA analysis that giving sulforaphane actually blocked the increase in the serum levels of corticosterone, adrenocorticotropic hormone, interleukin-6, and tumor necrosis factor in mice that were chronically stressed

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