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The latter factor is able to interact with thioredoxin to reduce a specific cysteine (Cys-62) in the Rel-homology domain (RHD) of the NF-kB subunit p50 that had been previously oxidized by ROS 34 , restoring its ability to interact with specific responsive DNA sequences 35,36

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Eur Heart J 41(2):255323 Dal Canto E, Ceriello A, Rydn L et al (2019) Diabetes as a cardiovascular risk factor: an overview of global trends of macro and micro vascular complications

doi: 10.1016/j.matbio.2017.12.016 103 PengDFuMWangMWeiYWeiX