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J Eur Acad Dermatol Venereol 2010

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However, through its regulatory function in amino acid metabolism, GPER may exert dual effects on different types of tumor cells: in breast and ovarian cancer cells, GPER activation increases amino acid metabolism, promoting tumor progression [227, 248], whereas in gastric and colorectal cancer cells, GPER activation inhibits key pathways affecting amino acid metabolism, thereby reducing amino acid metabolic utilization and lowering the metabolic state of tumor cells [236]

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