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Challenges and Future Directions of GLP-1 'Central Program' Intervention Current challenge: Individual differences and long-term safety Although GLP-1 injections have shown excellent efficacy in clinical trials, their "central plan" interventions still face challenges: Individual metabolic differences There are significant differences in the response of different patients to GLP-1RA, which are related to factors such as gene polymorphism, gut microbiota composition, and metabolic flexibility

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Additionally, if cold sensitivity is severe enough to cause numbness, tingling, or color changes in your fingers and toes, professional evaluation is important

Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using random-effects and fixed-effects models

They should have a BMI of 30 or higher (or 27 with related health conditions) and be under the care of a healthcare provider to ensure safe and effective use