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Proprotein convertase (PC) is an important enzyme that activates the product of the pro-glucagon gene by cleaving a peptide at the C-terminal domain, thereby enabling the biological activity of this peptide

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TGF-1 contributes to disease progression by promoting fibroblast proliferation, thickening of synovial tissue, and the breakdown of cartilage through enzymes such as aggrecanase-1

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