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Endocrinology 148(4):17641773 Hatch-McChesney A, Lieberman HR (2022) Iodine and iodine deficiency: a comprehensive review of a re-emerging issue

They may result from: 1) an inhibition of the homocysteine remethylation pathway that is a consequence of folate or vitamin B 12 deficiencies, or the presence of the thermolabile MTHFR mutation or a functional deficiency in methionine synthase

Allergy 77(10):29372948

An algorithm originally written to model sites of Cytochrome P450 metabolism (called XenoSite) finds clear patterns in molecular structure that identify sites of reactivity within reactive molecules with 90.8% accuracy and separate reactive and unreactive molecules with 80.6% accuracy

Its tricky to diagnose because it looks like a more serious blood disorder

Liu D, Wang LN, Li HX, Huang P, Qu LB, Chen FY