Frisch, M
Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalised anxiety disorder: an in vivo 3
FOXO4-DRI remains pre-clinical with no human trial data
The characteristics of glutathione are the following: (a) discovered by Hopkins in 1921 [67], (b) synthesized intracellularly by glutamate-cysteine ligase and glutathione synthetase [68], (c) exists in reduced (GSH) and oxidized (GSSG) forms, maintaining cellular redox balance [69], (d) functions in melanogenesis inhibition through tyrosinase suppression and pheomelanin synthesis [70], and (e) oral bioavailability is enhanced through liposomal formulations, S -acetyl derivatives, or co-administration with precursors [71]
10 THE AUTHORS References Eisen D
GemelliIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Universit Cattolica del Sacro Cuore, Rome, Italy