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The dermatitis score was evaluated the day after each DNCB application based on five symptoms: erythema/edema, dryness, erosion, excoriation, and lichenification, and each of the symptoms has 0 (none), 1 (mild), 2 (moderate), and 3 (severe) scores based on the skin lesion level ( Scratching behavior To investigate AD-like behavioral changes, the time of mice scratching the ear and dorsal skin in the hind paw for 30 min was measured after DBCB application, which was scored 0 (none), 2 (scratching shorter than 1.5 s), 4 (scratching longer than 1.5 s) ( Histological examination For histological analysis, paraffin-embedded tissues were sectioned at 4 m
Convenient daily stick no water needed
-EC and GSH standards and UDE augmented BV-2 intracellular GSH content In our previous observations, we noted the anti-neuroinflammatory effect of a 4 h incubation with 100 M of -EC, GSH, or UDE containing 100 M -EC against the generation of proinflammatory cytokines induced by LPS
Oxidative stress typically results from an imbalance between ROS production and antioxidant defenses
doi:10.2174/1570159x1 3666160502153022