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Blachier F, Beaumont M, Kim E

Furthermore, adjuvant pharmacotherapy was more effective in patients with higher BMI [30]

While everyone will experience fading over the course of the next 1-3 years and may get to a point where the freckles are undetectable to the client, there may always be slight residue of color depending on individual characteristics of a clients skin tone and lifestyle, etc There are always removal and/or lightening options available to anyone who feels their freckles no longer suit them

Khosravan et al., 2017), however it can induce various adverse reactions including itchiness, erythema, contact dermatitis, and ochronosis (McKesey et al., 2020

You need affordable medication and basic provider oversight

This is similar to how a bottle of water might develop small bubbles on the sides after being shaken