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This work shows that the stabilized stem subunit could be a potential antigen for a SARS-CoV-2 universal vaccine against unpredictable variants. The study found immunization with the stem induced balanced Immunoglobulin G (IgG) antibodies with potent and broad ADCC activity, a type of immune reaction in which infected cells are coated with antibodies that then recruit certain types of white blood cells to kill the infected cells
Additionally, extracellular succinate can be reuptake into cells, such as in brown adipose tissue under cold conditions, where it is taken up from the peripheral circulation and transported into mitochondria via SLC25A10 to participate in UCP1-dependent thermogenesis [77]
VoldenJSmithIMSzatmariPBrysonSFombonneEMirendaPet al
10.1016/j.plefa.2017.03.006 315
In conclusion, risk factors for kidney stones induce ferroptosis in the epithelial cells of the proximal tubules, and the chain of occurrence further accelerates the deposition and aggregation of crystals involved in kidney stone formation