OHarte, Ulster University, United Kingdom Updates Copyright 2023 Wang, Wang, Yang, Yang, Li, Jin, Zhang and Zhang
Strong investments from pharmaceutical companies are driving innovations and global availability
Because NNMT is involved in methylation and metabolic control, 5-Amino-1MQ is of interest in: Characterizing NNMT as a potential biomarker of tumor metabolism Studying how NNMT modulation may influence cancer cell proliferation, redox balance, and methyl-donor utilization Evaluating NNMT as a possible experimental target in oncology research At present, these efforts are confined to laboratory research
Although redressing the BA composition has proved to be beneficial in mouse models, it was unlikely to translate to human pathophysiology, as changes in BA composition in mice hardly reflect similar changes in BA profiles in humans due to the differences in BA composition 41
Do not pour it down the drain
doi: 10.1242/bio.046854