However, four putative mechanisms may underlie the association between elevated UA and the risk of CVD: association with cardiovascular risk factors, increased oxidative stress, increased inflammatory burden and a direct effect of UA on cellular processes leading to cellular (cardiac) dysfunction and injury
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Furthermore, ALC administration to human lens epithelial cells treated with homocysteine, restored (increased) the levels of antioxidant proteins, including SOD, GSH-Px, CAT, Nrf2, Keap1 and GSH [127]
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As extensively described elsewhere [for a review, see Koob (2014)], AUD involves recurring cycles of specific behaviors, involving an initial binge/reward phase followed by compulsive alcohol intake, which transitions into drinking with an aim to reduce the negative effects and the presence of withdrawal symptoms