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For example, PPIs (proton pump inhibitors) such as Nexium, Prilosec OTC, etc., have detrimental effects on the gut microbiota due to gastric acid suppression, leading to unwanted overgrowths of pathogens like helicobactor pylori, clostridia, and contributing to many other undesired effects on human health mediated through alteration of the gastrointestinal microbiome

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NPJ Metab Health Disease

[115] found that ALA (30120 mg/kg for one week, IP) alleviates neuropathic pain in STZ-induced diabetic rats by downregulating TRPV1 receptors via NF-B pathways, reducing neuronal excitability

2021) reported that AMP activity was diminished by administration of ethanol to pancreatic acinar cells, resulting in enhanced OS and production of inflammatory cytokines