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The Data: In 2026, a major Cochrane systematic review of 22 randomized trials found that intermittent fasting produced only modest results (average 25% weight loss), while semaglutide users typically see 15% to 20% reduction in total body weight

While gastrointestinal symptoms dominate the adverse effect profile, patients and clinicians have increasingly questioned whether these medications might contribute to musculoskeletal complaints, including muscle pain, weakness, or discomfort

Metabolism Changes A calorie deficit can lead to weight loss, but too much too soon can have negative consequences

The study found that semaglutide helped lower the risk of major heart events like heart attack, stroke, or death from heart problems

It is also approved by the FDA as a newer class of treatments for diabetes

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