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Additionally, the flavonoid nepetin has been reported to attenuate oxidative stress, suppress pro-inflammatory cytokines production, and reduce cell death by modulating the myeloid differentiation primary response 88 (MyD88) mitogen-activated protein kinase kinase 3/6 (MKK3/6) Akt signaling pathway, a potential role in the regulation of necroptosis or other non-apoptotic forms of programmed cell death (Gong et al., 2024)

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The response to NAC depends partly on the bodys capacity to synthesize glutathione, while direct formulations attempt to deliver glutathione or a protected derivative

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Nausea occurred at significantly elevated rates across all dose levels compared to placebo