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Similar protective mechanisms have also been observed in vascular endothelium, further highlighting the systemic nature of BPC-157 activity

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These findings may inform appropriate expectation setting for patients and clinicians and highlight the need for better methods of treatment selection for patients with degenerative lumbar spinal stenosis. Surgery caused adjacent segment disease A December 2025 study ( 20 ) explained that lateral lumbar interbody fusion (LLIF) works by indirectly providing decompression by restoring disc height

These effects are often transient and tend to subside as the body adapts or doses are titrated