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Smoking addiction is another critical condition that exacerbates obesity-related health risks, significantly increasing the likelihood of developing or reinforcing cardiovascular disease, type 2 diabetes, and chronic obstructive pulmonary disease (120)

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These substances generate oxidative stress, overwhelming the body's antioxidant defenses, including glutathione

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Clinical studies suggest that these granules, when combined with L-T4, can significantly lower TPOAb and TGAb titers, Th17 cells, and relevant cytokines compared to L-T4 treatment alone, while also enhancing the Treg/Th17 ratio, representing another intervention with supporting clinical evidence (Cao et al