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J Vasc Surg

HEP synthesis in liver is controlled by four pathways: (i) iron store-related regulation, (ii) erythropoietic activity-driven regulation, (iii) inflammation-related regulation, and (iv) mandatory signaling pathway

Furthermore, validation of the assay demonstrated linearity, as well as recoveries, of within 15% of expected values spanning the assays range, demonstrating the effectiveness of the SDS protocol to disrupt the IGF-1/IGFBP complex

PMID: 6244017

[4] An exception may be infants who are at an increased risk of deficiency regardless of the vitamin status of the mother during pregnancy and breast feeding due to poor transfer of the vitamin to the placenta and low amounts of the vitamin in breast milk