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Head-to-Head Efficacy: Tirzepatide Wins 22% vs 15% Weight Loss The most robust head-to-head comparison comes from the SURPASS-2 trial, a 40-week, phase 3 study of 1,879 adults with type 2 diabetes, published in the N Engl J Med

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However, Wegovy and Mounjaro are now available and approved for weight loss in the UK

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Just diet and exercise usually fail