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Bayesian data assimilation has been suggested as a method to integrate patient data and address uncertainty in individualized treatments, a strategy that may also be applicable to peptide-based therapeutics

It requires zinc for biological activity

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When combined with the exclusion of patients with either acute or chronic pancreatitis from prior clinical trials, this observation aligns with the caution raised by the American Diabetes Association to avoid use of GLP-1RAs for patients with any history of acute or chronic pancreatitis 27

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These findings may ultimately expand the indications for GLP-1RA therapy and solidify their role in precision CV risk reduction, for example in different subphenotypes of prediabetes and T2D