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According to current guidelines, they should be avoided if you are pregnant, hypersensitive to GLP-1, or living with severe gastrointestinal conditions such as inflammatory bowel disease (IBD)

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After that, the plate method or hand-portion method provides enough structure for most users to maintain appropriate intake without daily logging

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One study suggests that they work best in combination with amitriptyline, and recommends adjusting dosage of all three treatments based on blood levels