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The strongest human data comes from a 2022 study showing MOTS-c rises in skeletal muscle after long-term physical activity and improves acute exercise performance after a single dose (Hyatt et al., 2022, Physiological Reports, PMC9270643)

High atmospheric humidity impairs sweat evaporation the bodys primary cooling mechanism causing core temperature to rise and triggering heavier sweating, which accelerates fluid and mineral loss

doi: 10.1038/s41580-020-0230-3 3 ShekhovaE

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We thank research coordinator Michelle Poe for her superior dedication to all aspects of the study

This trial was small and preliminary