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doi: 10.1038/s41586-025-09460-7 118 GongKHuangYZhengYZhuYHaoWShiK

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19 Following further translocation to the mitochondria, activated phosphorylated JNK initiates a cascade in which JNK binds to the outer mitochondrial membrane scaffold protein Sab, inhibiting electron transport and thereby increasing the generation of ROS and peroxynitrite

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The underlying mechanism involves radiotherapy increasing the expression of interferon regulatory factor (IRF) 1 by activating the interferon signaling pathway