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Cell Death Dis 6:e1631 Gregorieff A, Liu Y, Inanlou MR, Khomchuk Y, Wrana JL (2015) Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

Having less muscle mass could also lead to feeling colder

(PubMed) Zheng Selin J, Rautiainen S, Lindblad BE, Morgenstern R, Wolk A

And some people have fewer side effects on one drug versus another

In ancient and medieval times, known antipyretic agents were compounds contained in white willow bark (a family of chemicals known as salicins, which led to the development of aspirin), and compounds contained in cinchona bark.[1] Cinchona bark was also used to create the anti-malaria drug quinine