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Looking forward, the future of SFN research lies in well-designed, biomarker-stratified clinical trials that incorporate advanced formulations and consider the complex interplay between diet, host genetics, and gut microbiota

Available at: (Accessed October 21, 2019)

596 Notably, memory loss in the PS2APP mouse AD model has been linked to astrocyte Ca 2+ hypoactivity due to reduced expression by astrocytes of the calcium sensor, STIM1

While our understanding of the regulation of the enzymes of the pathway has greatly increased, some aspects such as the moonlighting functions remain to be fully elucidated

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United States Pharmacopeial Convention I, Rockville, MD,