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On the other hand, conventional breeding, though limited in its potential for folate level improvement, is promising, as it might face lower regulatory restrictions compared with genetic engineering, hence allowing a more rapid implementation in agriculture, reaching the populations in need 756

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Furthermore, increasing the intracellular pool of coenzymes such as NADPH may be achieved through metabolic engineering approaches as described in other reviews (Lee et al., 2013)

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148,149,150,151 A randomized, double-blind, placebo-controlled clinical study showed that supplementation of Gln to the low fermentable oligo-monosaccharides and polyols (FODMAP) diet improves irritable bowel syndrome (IBS) symptoms