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Strategies such as HDAC inhibition, astrocyte transplantation and modulation of autophagy or metabolic pathways remain confined to experimental models, whereas GLP-1 receptor agonists and MAO-B inhibitors have advanced to clinical testing and show effects on astrocytic metabolism and neuroinflammation

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Only a small proportion (estimated 1-2%) of liraglutide circulates in the free (non-albumin bound) form, ready to diffuse into tissues and bind receptors

The fatigue profile tends to be milder with liraglutide, and some patients prefer the daily dosing because it provides more flexible dose adjustment opportunities