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Heres how specific conditions can impact the use of B12 shots: Heart Disease: While B12 is essential for overall health, excessive amounts of vitamin B12 in the body may sometimes cause an increase in certain heart disease risk markers, particularly for individuals with pre-existing cardiovascular conditions

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Therefore, they are not needed in large quantities

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10.1038/nature13148 110 MasaldanS.ClatworthyS

found that G6PD-d increases risk of ICAS in those aged 70 years or older, others studies have noted increased ASCVD risk in populations ranging from ~37 to 51 years old 18,19,20,21