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Researchers now understand that GLP-1 operates as a metabolic hormone while also serving as an anti-inflammatory agent that functions within synovial spaces

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Birngruber T, Raml R, Gladdines W, Gatschelhofer C, Gander E, Ghosh A, et al

Additionally, the diabetic kidney has increased oxygen demand due to increased sodium reabsorption and (single-nephron) hyperfiltration via increased Na + , K + ATPase activity at the basolateral surface of the tubules [13]