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Subgroup analysis indicated that homozygous mutations were associated with more severe impairment of long-term weight loss than heterozygous mutations, which explains why bi-allelic MC4R mutation carriers have poorer long-term outcomes than heterozygous carriers

These effects occurred without inducing aversive states or altering metabolic rate, suggesting selective action on appetite and satiety circuits

When this reabsorption process is impaired, excess bile acids reach the colon, where they stimulate water and electrolyte secretion, leading to chronic watery diarrhoea

When you are not feeling thirsty, it is easy to drink far less than your body actually needs