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When plants are subjected to insect herbivory or mechanical wounding, they rapidly activate the JA signaling pathway in whole plant tissues, which in turn mediates the systemic defense responses against insects 10,11,12,37

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46 Thus, the true utility of NAMPT as a cancer target may be in synergistic combinations that enable more effective targeting of known cancer-driving pathways by regulating the NAD + -dependent biology in these pathways

Raza H, John A, Shafarin J