A systematic review in 2025 identified one qualifying clinical study: a retrospective analysis in which 7 of 12 subjects with chronic knee pain reported relief for over six months following intra-articular injection
Potential Benefits of AOD-9604 Fat Breakdown and Body Composition The core mechanism of AOD-9604 is dual: it stimulates lipolysis (the breakdown of stored fat into free fatty acids the body can use for energy) while simultaneously inhibiting lipogenesis (the conversion of excess calories into new fat stores)
This effect occurs because artesunate induces the accumulation of p62, which in turn activates the Nrf2 pathway and promotes the expression of the downstream antioxidant enzymes HO-1 and NQO1
J Alloys Compd 779:962970
Kushner 1, Salvatore Calanna2, Melanie Davies3,4,5, Dror Dicker6,7, W
After the indicated incubation times, reactions were quenched by adding 1LmL cold KPBS, followed by two additional washes in 1LmL cold KPBS using the multiLchannel pipette