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These reductions translated into enhanced locomotor activity and lifespan extension in treated flies [44]

Importantly, genetic loss-of-function, rescue, and pharmacological inhibition analyses further demonstrated that intact MAPKAPK2 kinase activity, rather than protein expression alone, is indispensable for maintaining melanocyte resistance to oxidative stress

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Nat Commun 8: 1174 Hopkins L, Parmar S, Baszczyk A, Hesse H, Hoefgen R, Hawkesford MJ (2005) O-acetylserine and the regulation of expression of genes encoding components for sulfate uptake and assimilation in potato

When B12 is deficient, a buildup of methylmalonic acid occurs, which is toxic to the nervous system and contributes to neuropathy