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The first developed metformin prodrug, namely its cyclohexyl sulfenamide derivative, was in part activated on the apical side of the enterocytes with consequent decrease of absorbtion 121

A study found that by examining the postmortem brain tissue of suicidal patients with depression, the astrocyte-specific methylation map in the genome showed that glutamate receptor ionotropic kainate 2 and brain-rich guanosine kinase-related protein, which are associated with depressive psychopathology, were less methylated 134

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