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Phase I enzymes, including cytochrome P450 family members, initiate the oxidation of xenobiotics, while phase II enzymes like glutathione S-transferases and UDP-glucuronosyltransferases conjugate these metabolites for excretion (148)

Others have bacterial contamination or heavy metal residues

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For a patient whose entire complaint can be summarized as I cannot sleep and therefore everything else suffers, addressing the sleep deficiency directly before layering in energy or anabolic therapies is the more precise clinical decision

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