In the case of 2-hydroxyglutarate instead, it seems to induce an abnormal activity of telomerase reverse transcriptase (TERT), which in turn upregulates the transcription of important genes involved in stemness and tumorigenicity, including CD117, Oct4, and Sox2 [84, 85]
Hum Reprod Update 13(3):225238 Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJH, den Heijer M, Kluijtmans LAJ, van den Heuve LP, Rozen R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase
Biochim Biophys Acta Mol Basis Dis 2:585597 Cuadrado A, Martin-Moldes Z, Ye J, Lastres-Becker I (2014) Transcription factors NRF2 and NF-kappaB are coordinated effectors of the rho family, GTP-binding protein RAC1 during inflammation
Lastly, the number of studies was limited to predict the outcome related to the incidence of colorectal cancer associated with GLP-1 RA use
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