can you gain weight on glp 1 GLP-1 Genetics: How Genes Affect Appetite, Semaglutide, and Tirzepatide Response Weight Gain on Zepbound: Causes

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Billingham MEJ, Hicks C, Carney S

"For the newer GLP-1 medications, it would be useful to look at whether there are genetic variants, like the variants in PAM , that explain poor responders to their medications." "There are a whole class of medications that are insulin sensitizers, so perhaps we can develop medications that will allow people to be sensitized to GLP-1s or find formulations of GLP-1, like the longer-acting versions, that avoid the GLP-1 resistance." The research has been published in Genome Medicine .