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Hartman NR, Cysyk RL, Bruneau-Wack C, Thenot JP, Parker RJ, Strong JM

Patients are initiated on a gradual dosing schedule to optimize outcomes while minimizing potential side effects

For GLP-1 users specifically, the benchmarking approach is useful because it gives you concrete evidence of whether your strength is being preserved or declining during weight loss, something that is otherwise very difficult to track without baseline data

Post-Translational Modifications (PTMs): Many therapeutic peptides undergo PTMs (e.g., amidation, glycosylation) that impact their biological activity

disruptions in insulin signaling and chronic inflammation, hallmarks of obesity and dysmetabolism, greatly accelerate neurodegeneration