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Researchers at the University of British Columbia (UBC) found that patients taking GLP-1 drugs had a higher likelihood of developing stomach paralysis, pancreatitis, and bowel obstruction compared to individuals using bupropion-naltrexone, another weight loss medication

Instead, the absence of guidance reflects a lack of clinical data

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The Wall Street Journal reports that it found more than 50 sites selling what they dubiously termed pharmaceutical grade semaglutide and tirzepatide, the active ingredients on Ozempic, Wegovy, and Mounjaro

However, discontinuing the stack after 12+ weeks can produce a subjective 'crash' period of 710 days characterized by lethargy and appetite suppression as ghrelin signaling re-equilibrates