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Simultaneously, a prospective investigation proposed that LCIG patients exhibited similar PN patterns compared to those seen in oral LDopa patients (Loens et al

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In this configuration, Ras-GTP binds to and activates the serine/threonine kinase RAF, which in turn will activate MEK (MAPK/ERK kinase), and consequently, this kinase phosphorylates and activates MAPK/ERK (extracellular signal-regulated kinase) (56)

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While dietary tryptophan is primarily absorbed intestinally for protein synthesis, colonic microbiota extensively catabolize residual tryptophan through multiple pathways