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The mechanism of action

Electrolytes (sodium, potassium, magnesium) may be important if a patient experiences significant GI side effects like severe vomiting or diarrhea

This aspect of the study focused on muscle responses to acetylcholine, a neurotransmitter involved in muscle contraction, and electrical field stimulation, a method used to mimic nerve impulses that trigger muscle contraction

Based on the displayed structures, and in particular with that of the glutathione conjugate of etacrynic acid [132], which is itself a Michael acceptor, it is well conceivable that glutathione acrylate can dock into the glutathione activating pocket of the GST enzymes and irreversibly bind to the essential tyrosine phenolate function, thus inactivating the enzyme