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Uremic solutes, including indoxyl sulfate and p-cresyl sulfate, not only stimulate cytokine release via toll-like receptor 4 (TLR4) activation in immune cells but also prime erythrocytes for cytokine-derived Ca 2+ influx by weakening antioxidative mechanisms (e.g., depleting glutathione) (Dinkla et al., 2016

Moreover, Prevotella was linked to preclinical symptoms in individuals at high risk for RA, particularly immediate relatives of RA patients [79]