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Key points: GI side effects are most common: nausea, diarrhea, and decreased appetite They usually improve: most patients adapt within 4-8 weeks Start low, go slow: the escalation schedule exists for a reason Stay hydrated and modify your diet: simple changes make a big difference Communicate with your provider: don't suffer unnecessarily Sources SURMOUNT-1 Clinical Trial (Jastreboff et al., NEJM 2022) SURPASS-1 Clinical Trial (Rosenstock et al., NEJM 2021) Mounjaro Prescribing Information, Eli Lilly Zepbound Prescribing Information, Eli Lilly Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice

Gut microorganisms influence neurotransmitter production, such as serotonin and GABA, adding a layer of neuroendocrine control over fertility by affecting GnRH pulsatility and hypothalamic communication (259)

10.1016/j.jfda.2016.03.010 82 LiX.JinQ.YaoQ.XuB.LiL.ZhangS.et al (2018)