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Proc Natl Acad Sci 72:43764380

The report, New Weight Loss Drugs: GLP-1 Agonist Use and Side Effects in the United States, is available at www.rand.org

Experimental study on humans

It stimulates the liver to release more glucose into the bloodstream (gluconeogenesis), and it reduces how well peripheral tissues like muscle and fat respond to insulin

Taking a dose too early may slightly increase the risk of side effects such as nausea, vomiting, or abdominal discomfort, but is unlikely to affect the overall effectiveness of treatment

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