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Active site residues U46, R48, Q81, and W136 are highlighted and shown as sticks

Importantly, many ncRNAs act by sponging or modulating each others availability, creating regulatory networks that fine-tune responses to oxidative stress in melanocytes and neighboring skin cells 104,109

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doi: 10.1038/nrc.2016.114 82 TarditoSOudinAAhmedSUFackFKeunenOZhengLet al

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This regulation is facilitated by the action of hormones (glucagon and insulin), central and peripheral nervous system, as well as metabolic requirements of the body [37]