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In weeks 9-12, the dosage will be escalated to 7.5 mg once weekly if tolerated by the patient

FIGURE 1 Markov Clustering analysis (inflation parameter of 2) resulted in two protein subnetworks, as shown in Figure 1

Furthermore, phosphomimetic substitution (S/T E) of the 12 DNA-PK consensus sites inhibits FUS-PrLD-induced phase separation and forms fibrillated aggregates in vitro 82

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When intestinal I/R injury occurs, the tight junctions between intestinal epithelial cells become compromised, leading to increased intestinal permeability, a phenomenon often referred to as leaky gut (Liu et al., 2023)